10 Best Spot On Flea Treatment For Dogs Large in The UK
Last updated on 05/09/2025
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Best Choice
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FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 6 Pipettes
FRONTLINE
46% OffFree Shipping
FRONTLINE
FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 6 Pipettes
46% OffFree Shipping
Why We Love It
- Kills fleas within 24 hours.
- Kills ticks within 48 hours.
- Simple, quick application process.
Main Highlights
- KILLS FLEAS - Fleas jumping onto your treated dog are killed within 24 hours, preventing infestations from building up
- KILLS TICKS - Ticks latching onto your treated dog are killed within 48 hours, helping to reduce the risk of disease transmission
- TRIED AND TRUSTED - FRONTLINE's original vet-strength formula has an exemplary safety profile
- EASY APPLICATION - Simply empty one pipette onto your dog's skin at the back of the neck and it will quickly spread over their coat - it's as easy as that
- TREAT MONTHLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 6-pack provides your dog with 6 months of protection
Value for Money
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Dog Flea Treatment Large Dog x 6 - Spot on Flea Treatment for Dogs Large 20-40 kg - FleaSolve 6 Pipettes, 6 Doses - Effective Spot-On Treatment
Naqua Ltd
Free Shipping
Naqua Ltd
Dog Flea Treatment Large Dog x 6 - Spot on Flea Treatment for Dogs Large 20-40 kg - FleaSolve 6 Pipettes, 6 Doses - Effective Spot-On Treatment
Free Shipping
Why We Love It
- Rapid relief from fleas.
- Effortless spot-on application.
- Vet-strength without prescription.
Main Highlights
- Flea treatment for dogs: Say goodbye to pesky fleas! Our fast-acting spot on flea treatment for dogs provides immediate relief for your furry friend by killing fleas instantly and ticks within 24 - 48 hours using dog flea treatment Large dog.
- Tick Off Ticks Too: Flea and tick treatment for dogs! This formula also serves as a dog tick treatment, killing ticks and reducing the risk of disease transmission.
- Spot on flea treatment for dogs: Hassle-Free Application. Our spot on tick and flea treatment uses a pipette that is pressed on the back of the dog’s neck to ensure that every drop gets on their coat quickly.
- No Vet Visit Required: Flea treatment for dogs Large contains fipronil, a strong, vet-strength ingredient, which provides swift relief from infestation and itch without a prescription for dogs.
- Large Dog Flea Treatment: Year-Round Protection. With our monthly treatment plan, there's no need to fret about flea or tick seasons. You can enjoy peace of mind knowing your pet is shielded all year long.
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FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 3 Pipettes
FRONTLINE
28% OffFree Shipping
FRONTLINE
FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 3 Pipettes
28% OffFree Shipping
Why We Love It
- Kills fleas in 24 hours.
- Kills ticks within 48 hours.
- Easy monthly application.
Main Highlights
- KILLS FLEAS - Fleas jumping onto your treated dog are killed within 24 hours, preventing infestations from building up
- KILLS TICKS - Ticks latching onto your treated dog are killed within 48 hours, helping to reduce the risk of disease transmission
- TRIED AND TRUSTED - FRONTLINE's original vet-strength formula has an exemplary safety profile
- EASY APPLICATION - Simply empty one pipette onto your dog's skin at the back of the neck and it will quickly spread over their coat - it's as easy as that
- TREAT MONTHLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 3-pack provides your dog with 3 months of protection
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Itch | Flea & Tick Spot-On Treatment for Large dogs (20-40kg) | Kills Fleas, Ticks, Lice & Eggs to Prevent Reinfestation | 3 Easy-Apply Pipettes
Itch
16% OffFree Shipping
Itch
Itch | Flea & Tick Spot-On Treatment for Large dogs (20-40kg) | Kills Fleas, Ticks, Lice & Eggs to Prevent Reinfestation | 3 Easy-Apply Pipettes
16% OffFree Shipping
Why We Love It
- Kills fleas, ticks, eggs.
- Vet-strength double action formula.
- Safe for all dogs.
Main Highlights
- KILLS FLEAS & TICKS EFFECTIVELY: Each treatment of Itch Flea effectively kills fleas in 24 hours, ticks in 48 hours and protects them for up to a month! Got a flea infestation? Use Itch Flea monthly, alongside Itch Flea Home Spray to tackle the microscopic mingers on your pet and home.
- VET STRENGTH FORMULA WITH TWO ACTIVE INGREDIENTS: Fipronil kills live adult fleas, lice and ticks. Unlike cheaper brands, Itch Flea also includes (S) Methoprene. This prevents flea eggs from hatching, larvae from maturing, and immature stages from developing into adult fleas, preventing flea reproduction and massively reducing the chance of a returning infestation.
- PREVENTS FLEAS COMING BACK (UNLIKE CHEAPER BRANDS) BY KILLING FLEAS, EGGS & LARVAE TOO: Not all flea treatments are equal. Our double-action formula attacks fleas, flea eggs and larvae, breaking the flea life cycle and preventing fleas coming back. Because, seriously, who wants that?
- PROTECT FROM TICKS - Ticks are a threat because they carry serious diseases including Lyme Disease, Babesiosis and Tick-Borne Encephalitis Virus (TBEV) all of which can cause severe health complications for you or your dog. Itch Flea kills ticks. It won’t stop the pests from latching on, but it will kill them within 48 hours – dramatically reducing the chances of them transmitting a nasty infection.
- PROTECTION FOR ADULT DOGS AND PUPPIES - Pick the right size for your dog or puppy over 8 weeks old. Contains 3 treatments to be used at monthly intervals as to protect your pet from further flea issues! Itch Flea is safe for all dogs above 2kg, including those who are breeding, pregnant or lactating.
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FRONTLINE Plus Flea & Tick Treatment for Large Dogs - 3 Pipettes
FRONTLINE
29% OffFree Shipping
FRONTLINE
FRONTLINE Plus Flea & Tick Treatment for Large Dogs - 3 Pipettes
29% OffFree Shipping
Why We Love It
- Kills fleas fast and effectively.
- Prevents re-infestation with ease.
- Easily applied in seconds.
Main Highlights
- KILLS FLEAS & TICKS – Fleas are killed within 24 hours and ticks within 48 hours, helping to protect dogs from the discomfort and diseases these parasites cause
- KILLS FLEA EGGS - Unlike most flea treatments, FRONTLINE Plus not only kills fleas but also stops their eggs from hatching and infesting the home
- TRIED AND TRUSTED - FRONTLINE's advanced vet-strength formula is highly efficacious and yet has an exemplary safety profile.
- EASY APPLICATION - Simply empty one pipette onto your dog's skin at the base of the neck and it will quickly spread over their coat - it's as easy as that
- TREAT 4-WEEKLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 3-pack provides your dog with 3 months of protection
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Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks
Advantage
Advantage
Advantage Spot On Flea Treatment For Extra Large Dogs 25 - 40kg (4 pipettes, 400mg), Kills Fleas Within 24 Hours, Prevents Further Infestation For Up To Four Weeks
Why We Love It
- Prevents flea infestation effectively.
- Easy-to-apply single use.
- Lasts for four weeks.
Main Highlights
- ADVANTAGE FLEA TREATMENT: Use Spot On Flea Treatment to keep your pets protected from fleas. Advantage spreads quickly across your pet’s skin and coat and is not absorbed into the bloodstream, meaning those pesky parasites do not have to bite to die 1.
- FAST-ACTING FLEA PROTECTION: If you suspect your pet might be suffering with fleas, take action. Advantage kills fleas within 24 hours of application, meaning your pet can get back to living a full and happy life.
- PREVENT REINFESTATION: For every adult flea that you see, there are many more eggs, larvae and pupae hidden away in carpets, upholstery and bedding. Apply spot on treatment every four weeks to prevent further infestations.
- FAST & SIMPLE TO APPLY: Protect your pets from fleas with our easy to apply pipette formulation. Apply one pipette evenly to three to four spots on the top of the back from the shoulder to the base of the tail.
- PROTECT YOUR PET, PROTECT YOUR HOME: If your pet has fleas, your home has fleas. Advantage is clinically proven to kill fleas, giving you peace of mind. With Advantage Flea Treatment, fleas are dead, not fed.
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Bob Martin Clear Spot On Flea Treatment for Large Dogs (20-40kg) - Kills Fleas & Ticks (3 Pipettes)
Bob Martin
Free Shipping
Bob Martin
Bob Martin Clear Spot On Flea Treatment for Large Dogs (20-40kg) - Kills Fleas & Ticks (3 Pipettes)
Free Shipping
Why We Love It
- Effective and speedy flea treatment.
- Specially designed for large dogs.
- Ensures precise and easy application.
Main Highlights
- KILLS FLEAS & TICKS - Effective spot-on treatment, simply apply directly on your dogs skin to kill fleas within 24 hours and ticks within 48 hours.
- LARGE DOGS (20-40KG) - Suitable for large dogs over 8 weeks old, weighing between 20-40kg.
- HOW TO USE - Simply part your cats fur until the skin is visible, place the tip of the pipette directly against the skin and gently squeeze. Apply half to the base of the back of your dogs head and half between the shoulder blades.
- PROTECT YOUR PET - Prevents re-infestation on your pet and in their immediate surroundings. The active ingredient (Fipronil) works quickly to kill fleas & ticks.
- LONG TERM PROTECTION - Kills Fleas for up to 8 weeks and kills ticks for up to 4 weeks
- PREVENTATIVE CARE IS THE BEST CARE - Contains 3 x spot-on pipettes to be used at monthly intervals as part of an effective and regular flea control program.
- MAXIMISE YOUR PROTECTION - Use with Bob Martin Clear Plus Flea Spray for a complete parasite control regime.
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Beaphar | FIPROtec Spot-On for Extra Large Dogs (40–60kg) | Kills Fleas & Ticks | Vet Strength Treatment | 4 Pipettes
Beaphar
Free Shipping
Beaphar
Beaphar | FIPROtec Spot-On for Extra Large Dogs (40–60kg) | Kills Fleas & Ticks | Vet Strength Treatment | 4 Pipettes
Free Shipping
Why We Love It
- Kills fleas within 24 hours.
- Effective for up to month.
- Vet strength, easy application.
Main Highlights
- KILLS FLEAS AND TICKS: Beaphar FIPROtec Spot-On for Extra Large Dogs is an effective and affordable veterinary medicine to control fleas and ticks on your dog, killing fleas within 24 hours and ticks within 48 hours.
- MONTHLY TREATMENT: Effective against fleas for up to five weeks. Prevention is the best way to protect your dog from fleas and ticks. Treatment can be used every four weeks
- EASY TO APPLY: Simply part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently to empty its contents onto the skin. The active formula will then spread across the body and keep your dog protected
- SUITABLE FOR DOGS AND PUPPIES: Can be used on dogs and puppies from 8 weeks of age weighing 40-60kg
- VET STRENGTH TREATMENT: Beaphar FIPROtec Spot-On for Extra Large Dogs is a veterinary medicine available without the need for a veterinary prescription. It contains fipronil which effects the nervous system of fleas, causing hyperactivity. As a result, it is quite common to see 'more' fleas following treatment
- DEALING WITH A FLEA INFESTATION: Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings. For best results, use with Beaphar FLEAtec Household flea spray to help tackle the infestation in the home
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Effipro Flea & Tick Spot-On for Large Dogs 20-40kg | Fast-Acting | 4 Pipettes | Vet-Strength Formula | Easy to Apply
Effipro
28% OffFree Shipping
Effipro
Effipro Flea & Tick Spot-On for Large Dogs 20-40kg | Fast-Acting | 4 Pipettes | Vet-Strength Formula | Easy to Apply
28% OffFree Shipping
Why We Love It
- Topical application is easy.
- Prevents licking from animals.
- Effective treatment for skin care.
Main Highlights
- FAST-ACTING FLEA & TICK CONTROL – Kills fleas within 24 hours and ticks within 48 hour, providing rapid relief for your dog.
- LONG-LASTING PROTECTION – Offers up to 8 weeks of flea protection and 4 weeks against ticks with a single application.
- EASY APPLICATION – Unique drop-lock pipette ensures precise, mess-free application, making treatment simple for both you and your dog.
- SUITABLE FOR LARGE DOGS – For dogs weighing 20–40kg and over 8 weeks old.
- AUTHORISED VETERINARY MEDICINE – Approved and licenced by the Veterinary Medicines Directorate (VMD).
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Dog Flea Treatment Extra Large Dogs x 2 - Flea Treatment for Dogs XL Very Large Dog 40-60 kg - Spot-On Solution for Fleas and Tick Control - FleaSolve 2 x Pipettes, 2 x Doses
Naqua Ltd
Free Shipping
Naqua Ltd
Dog Flea Treatment Extra Large Dogs x 2 - Flea Treatment for Dogs XL Very Large Dog 40-60 kg - Spot-On Solution for Fleas and Tick Control - FleaSolve 2 x Pipettes, 2 x Doses
Free Shipping
Why We Love It
- Fast-acting relief for dogs.
- Easy applicator for stress-free use.
- Year-round protection from pests.
Main Highlights
- Flea treatment for dogs: Say goodbye to pesky fleas! Our fast-acting spot on flea treatment for dogs provides immediate relief for your furry friend by killing fleas instantly and ticks within 24 - 48 hours using dog flea treatment Extra Large dog.
- Tick Off Ticks Too: Flea and tick treatment for dogs! This formula also serves as a dog tick treatment, killing ticks and reducing the risk of disease transmission.
- Spot on flea treatment for dogs: Hassle-Free Application. Our spot on tick and flea treatment uses a pipette that is pressed on the back of the dog’s neck to ensure that every drop gets on their coat quickly. Effective XL Dog flea treatment.
- No Vet Visit Required: Flea treatment for dogs Large contains fipronil, a strong, vet-strength ingredient, which provides swift relief from infestation and itch without a prescription for dogs.
- Large Dog Flea Treatment: Year-Round Protection. With our monthly treatment plan, there's no need to fret about flea or tick seasons. You can enjoy peace of mind knowing your pet is shielded all year long.