10 Best Spot On Flea Treatment For Dogs Large in The UK

Last updated on 16/07/2025

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9.9

Exceptional

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FRONTLINE

FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 6 Pipettes

39% OffFree Shipping

Why We Love It

Kills fleas within 24 hours.
Kills ticks within 48 hours.
Simple, quick application process.

Main Highlights

KILLS FLEAS - Fleas jumping onto your treated dog are killed within 24 hours, preventing infestations from building up
KILLS TICKS - Ticks latching onto your treated dog are killed within 48 hours, helping to reduce the risk of disease transmission
TRIED AND TRUSTED - FRONTLINE's original vet-strength formula has an exemplary safety profile
EASY APPLICATION - Simply empty one pipette onto your dog's skin at the back of the neck and it will quickly spread over their coat - it's as easy as that
TREAT MONTHLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 6-pack provides your dog with 6 months of protection

FRONTLINE Plus Flea & Tick Treatment for Large Dogs - 3 Pipettes

29% OffFree Shipping

Why We Love It

Kills fleas fast and effectively.
Prevents re-infestation with ease.
Easily applied in seconds.

Main Highlights

KILLS FLEAS & TICKS – Fleas are killed within 24 hours and ticks within 48 hours, helping to protect dogs from the discomfort and diseases these parasites cause
KILLS FLEA EGGS - Unlike most flea treatments, FRONTLINE Plus not only kills fleas but also stops their eggs from hatching and infesting the home
TRIED AND TRUSTED - FRONTLINE's advanced vet-strength formula is highly efficacious and yet has an exemplary safety profile.
EASY APPLICATION - Simply empty one pipette onto your dog's skin at the base of the neck and it will quickly spread over their coat - it's as easy as that
TREAT 4-WEEKLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 3-pack provides your dog with 3 months of protection

FRONTLINE Spot On Flea & Tick Treatment for Small Dog (2-10kg) 3 Pipettes

16% OffFree Shipping

Why We Love It

Kills fleas within 24 hours.
Reduces disease transmission risk.
Easy and quick application.

Main Highlights

KILLS FLEAS - Fleas jumping onto your treated dog are killed within 24 hours, preventing infestations from building up
KILLS TICKS - Ticks latching onto your treated dog are killed within 48 hours, helping to reduce the risk of disease transmission
TRIED AND TRUSTED - FRONTLINE's original vet-strength formula has an exemplary safety profile and can be used on puppies weighing more than 2 kg, from 8 weeks of age
EASY APPLICATION - Simply empty one pipette onto your dog's skin at the back of the neck and it will quickly spread over their coat - it's as easy as that
TREAT MONTHLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 3-pack provides your dog with 3 months of protection

FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 3 Pipettes

28% OffFree Shipping

Why We Love It

Kills fleas in 24 hours.
Kills ticks within 48 hours.
Easy monthly application.

Main Highlights

KILLS FLEAS - Fleas jumping onto your treated dog are killed within 24 hours, preventing infestations from building up
KILLS TICKS - Ticks latching onto your treated dog are killed within 48 hours, helping to reduce the risk of disease transmission
TRIED AND TRUSTED - FRONTLINE's original vet-strength formula has an exemplary safety profile
EASY APPLICATION - Simply empty one pipette onto your dog's skin at the back of the neck and it will quickly spread over their coat - it's as easy as that
TREAT MONTHLY - It’s important to treat your pets year-round to prevent flea and tick infestations. One 3-pack provides your dog with 3 months of protection

Bob Martin Clear Spot On Flea Treatment for Large Dogs (20-40kg) - Kills Fleas & Ticks (3 Pipettes)

8% Off

Why We Love It

Effective and speedy flea treatment.
Specially designed for large dogs.
Ensures precise and easy application.

Main Highlights

KILLS FLEAS & TICKS - Effective spot-on treatment, simply apply directly on your dogs skin to kill fleas within 24 hours and ticks within 48 hours.
LARGE DOGS (20-40KG) - Suitable for large dogs over 8 weeks old, weighing between 20-40kg.
HOW TO USE - Simply part your cats fur until the skin is visible, place the tip of the pipette directly against the skin and gently squeeze. Apply half to the base of the back of your dogs head and half between the shoulder blades.
PROTECT YOUR PET - Prevents re-infestation on your pet and in their immediate surroundings. The active ingredient (Fipronil) works quickly to kill fleas & ticks.
LONG TERM PROTECTION - Kills Fleas for up to 8 weeks and kills ticks for up to 4 weeks
PREVENTATIVE CARE IS THE BEST CARE - Contains 3 x spot-on pipettes to be used at monthly intervals as part of an effective and regular flea control program.
MAXIMISE YOUR PROTECTION - Use with Bob Martin Clear Plus Flea Spray for a complete parasite control regime.

Dog Flea Treatment - Extra Large Dogs x 4 - Spot on Flea Treatment for Dogs XL Very Large Dog 40-60 kg - Flea and Tick Control - Fast Acting FleaSolve Solution - 4 Pipettes

Free Shipping

Why We Love It

Rapid relief guaranteed for dogs.
Hassle-free, quick application.
Year-round protection assured.

Main Highlights

Flea treatment for dogs: Say goodbye to pesky fleas! Our fast-acting spot on flea treatment for dogs provides immediate relief for your furry friend by killing fleas instantly and ticks within 24 - 48 hours using dog flea treatment Extra Large dog.
Tick Off Ticks Too: Flea and tick treatment for dogs! This formula also serves as a dog tick treatment, killing ticks and reducing the risk of disease transmission.
Spot on flea treatment for dogs: Hassle-Free Application. Our spot on tick and flea treatment uses a pipette that is pressed on the back of the dog’s neck to ensure that every drop gets on their coat quickly. Effective XL Dog flea treatment.
No Vet Visit Required: Flea treatment for dogs Large contains fipronil, a strong, vet-strength ingredient, which provides swift relief from infestation and itch without a prescription for dogs.
Large Dog Flea Treatment: Year-Round Protection. With our monthly treatment plan, there's no need to fret about flea or tick seasons. You can enjoy peace of mind knowing your pet is shielded all year long.

Dog Flea Treatment Large Dog x 6 - Spot on Flea Treatment for Dogs Large 20-40 kg - FleaSolve 6 Pipettes, 6 Doses - Effective Spot-On Treatment

Free Shipping

Why We Love It

Rapid relief from fleas.
Effortless spot-on application.
Vet-strength without prescription.

Main Highlights

Flea treatment for dogs: Say goodbye to pesky fleas! Our fast-acting spot on flea treatment for dogs provides immediate relief for your furry friend by killing fleas instantly and ticks within 24 - 48 hours using dog flea treatment Large dog.
Tick Off Ticks Too: Flea and tick treatment for dogs! This formula also serves as a dog tick treatment, killing ticks and reducing the risk of disease transmission.
Spot on flea treatment for dogs: Hassle-Free Application. Our spot on tick and flea treatment uses a pipette that is pressed on the back of the dog’s neck to ensure that every drop gets on their coat quickly.
No Vet Visit Required: Flea treatment for dogs Large contains fipronil, a strong, vet-strength ingredient, which provides swift relief from infestation and itch without a prescription for dogs.
Large Dog Flea Treatment: Year-Round Protection. With our monthly treatment plan, there's no need to fret about flea or tick seasons. You can enjoy peace of mind knowing your pet is shielded all year long.

Effipro Spot On for Large Dogs, 20-40kg, 4 Pipettes

Why We Love It

Topical application is easy.
Prevents licking from animals.
Effective treatment for skin care.

Main Highlights

Administer by topical application to the skin.
It is important to make sure that the product is applied to an area where the animal cannot lick it off
make sure that animals do not lick each other following treatment.

Beaphar | FIPROtec Spot-On for Large Dogs (20–40kg) | Kills Fleas & Ticks | Vet Strength Treatment | 6 Pipettes

30% OffFree Shipping

Why We Love It

Kills fleas within 24 hours.
Affordable veterinary-grade treatment.
Easy to apply.

Main Highlights

KILLS FLEAS AND TICKS: Beaphar FIPROtec Spot-On for Large Dogs is an effective and affordable veterinary medicine to control fleas and ticks on your dog, killing fleas within 24 hours and ticks within 48 hours.
MONTHLY TREATMENT: Effective against fleas for up to five weeks. Prevention is the best way to protect your dog from fleas and ticks. Treatment can be used every four weeks.
EASY TO APPLY: Simply part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently to empty its contents onto the skin. The active formula will then spread across the body and keep your dog protected.
SUITABLE FOR DOGS AND PUPPIES: Can be used on dogs and puppies from 8 weeks of age weighing 20-40kg.
VET STRENGTH TREATMENT: Beaphar FIPROtec Spot-On for Large Dogs is a veterinary medicine available without the need for a veterinary prescription. It contains fipronil which effects the nervous system of fleas, causing hyperactivity. As a result, it is quite common to see 'more' fleas following treatment.
DEALING WITH A FLEA INFESTATION: Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings. For best results, use with Beaphar FLEAtec Household flea spray to help tackle the infestation in the home.

Advantage Spot On Flea Treatment 400 Extra Large Dogs 25-40kg, 4 pipettes

Why We Love It

Prevents flea infestation effectively.
Easy-to-apply single use.
Lasts for four weeks.

Main Highlights

One treatment prevents further flea infestation for up to four weeks on dogs
Advantage Flea Treatment is supplied in 1 pack containing 4 single use pipettes
Treatment should be repeated after four weeks

8.8

Excellent

We scanned 1315 products

We reviewed these offers relevant to the Spot On Flea Treatment For Dogs Large within online retailers such as Amazon, eBay and other local retailers, ensuring we covered all major brands and models. The products we selected come from trusted brands like FRONTLINE, Bob Martin, Naqua Ltd, Effipro, Beaphar, Advantage, all of which have a reputation for consistently delivering high-quality products that users love and innovative approaches for function & design.

For the best Spot On Flea Treatment For Dogs Large in the market, we considered we took a deep dive into 6576 online reviews , focusing on elements like user satisfaction, performance in real-world conditions, and long-term reliability. Our ranking also evaluates each review’s relevancy, authenticity, up-to-dateness and depth so that the comparison is more sound.

We concluded that:

The clear winner of our analysis is FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 6 Pipettes. We love many things about this product by FRONTLINE. What sets it apart from the competition is Kills fleas within 24 hours, Kills ticks within 48 hours, Simple, quick application process.
The best value product for most shoppers and where user satisfaction is continuously the highest is FRONTLINE Plus Flea & Tick Treatment for Large Dogs - 3 Pipettes by FRONTLINE based on online reviews by bloggers, experts and online shoppers.
The biggest bargain at the moment for Spot On Flea Treatment For Dogs Large and the best cost-to-value ratio is FRONTLINE Spot On Flea & Tick Treatment for Large Dog (20-40kg) 6 Pipettesat FRONTLINE with a 39% discount.
Our list of the best Spot On Flea Treatment For Dogs Large is updated regularly to reflect new releases and changes in product availability, so be sure to check back often for the latest rankings and discounts.

10 Best Spot On Flea Treatment For Dogs Large in The UK

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We scanned 1315 products

We concluded that: